The specificity triad: notions of disease and therapeutic specificity in biomedical reasoning

The specificity triad: notions of disease and therapeutic specificity in biomedical reasoning

Biomedicine is typically defined as the branch of medicine that is based on the principles of biology and biochemistry. A central tenet for biomedicine is the notion of disease and therapeutic specificity, i.e. the idea of tailored treatments for discrete disorders underpinned by specific pathologies. The present paper is concerned with how notions of disease and therapeutic specificity guide b...

Immunological specificity of Staphylococal penicillinase

Sensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis

  Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NIC...

STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...

Specificity and Inheritance in Default Reasoning

When specificity considerations are incorporated in default reasoning systems, it is hard lo ensure that exceptional subclasses inherit all legitimate features of their parent classes To reconcile these two requirements specificitv and inheritance, this paper proposes the addi­ tion of a new rule called coherence rule, to the desiderata for default inference The coherence rule captures the intu...